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Bücher für Medizin, Wissenschaft und Studium

Pneumologie
Pneumologie - Onkologie

Lung Cancer is a comprehensively revised and expanded edition the well-established, concise, multidisciplinary reference book dealing with advances in lung cancer clinical research and treatment for the clinician. Edited and authored by leading authorities in the field, it is the best concise single source for state-of-the-art diagnosis and treatment of lung cancer. The new fourth edition is now better than ever, incorporating the most recent work in the field of lung cancer research, diagnosis, and treatment. This book has always been well known and highly regarded for its concise presentation, but the editors decided to add 9 new chapters to this latest edition, while tightening the presentation in existing chapters and consolidating and re-formatting several other chapters so that an additional 7 chapters are nearly brand-new in content and approach: Almost half of this edition is new! The reader will now find here the very latest research in the identification of biomarkers to predict a high risk for developing lung cancer, which is vital information for implementing screening and prevention strategies. Also included is the newest lung cancer staging system, as well as a variety of surgical and radiation therapy techniques that make local tumor control more effective and less invasive. There is useful discussion of combined modality therapy and new chemotherapeutic agents, which are yielding higher response rates and improved survival when used in the adjuvant setting. Nearly a third of the book offers novel and emergent approaches to preventative, diagnostic, and therapeutic modalities in the treatment of lung cancer, with an emphasis on the best evidence available from the latest studies and clinical trials.

Contributors

Preface

1 Smoking Prevention and Cessation
Alexander V. Prokhorov and Karen Suchanek Hudmon

2 Lung Cancer Susceptibility and Risk Assessment Models
Xifeng Wu, Xia Pu, and Jie Lin

3 Molecular Profiling
Lauren Averett Byers

4 Somatic Genome Alterations in Human Lung Cancers
Marcin Imielinski, Peter S. Hammerman, Roman Thomas, and Matthew Meyerson

5 Serum Proteomic Biomarkers
Mohamed Hassanein and David P. Carbone

6 Molecular Biology of Lung Preneoplasia
Humam Kadara and Ignacio I. Wistuba

7 Detection and Treatment of Preneoplastic Lesions
Rachel Jen and Stephen Lam

8 Pathology of Adenocarcinoma
William D. Travis

9 Management of Multi-Focal Bronchioloalveolar Carcinoma (BAC)
Howard West

10 Radiology and Lung Cancer Screening
Patricia de Groot and Reginald F. Munden

11 Imaging Lung Cancer
Sonia L. Betancourt Cuellar , Edith M. Marom, and Jeremy J. Erasmus

12 Staging of the Mediastinum
Mauricio Pipkin and Shaf Keshavjee

13 Management of the Solitary Pulmonary Nodule
Min P. Kim

14 Minimally Invasive Resections for Lung Cancer
Shanda H. Blackmon

15 Extended Resections for Lung Cancer
Matthew A. Steliga and David C. Rice

16 Bronchoscopic Interventions for Lung Cancer
Donald R. Lazarus and George A. Eapen

17 Primary Tracheal Tumors
Francesco Sannmartino and Paolo Macchiarini

18 Adjuvant Chemotherapy Following Surgery for Lung Cancer
Kathryn A. Gold

19 Neoadjuvant Chemotherapy for Resectable Non-Small Cell Lung Cancer
Christopher G. Azzoli and Katherine M.W. Pisters

20 Image-guided Radiation Therapy
Kenneth E. Rosenzweig and Sonal Sura

21 Stereotactic Ablative Radiotherapy for Lung Cancer
Puneeth Iyengar and Robert D. Timmerman

22 Proton Therapy
Joe Y. Chang and James D. Cox

23 Combinations of Radiation Therapy and Chemotherapy for Non-Small Cell and Small-Cell Lung Carcinoma
Daniel Gomez, Zhongxing Liao, Pierre Saintigny, and Ritsuko Komaki

24 Individualized Radiotherapy Dose Escalation and Acceleration in Lung Cancer
Heath D. Skinner, Ritsuko Komaki, Joe Y. Chang, and James D. Cox

25 Molecular Target Treatment for Personalized Radiotherapy in Lung Cancer
Steven H. Lin and Ritsuko Komaki

26 EGFR Tyrosine Kinase Inhibitors and Monoclonal Antibodies: Clinical Trial Review Kathryn F. Mileham, Edward S. Kim, and William N. William, Jr

27 Mechanisms of Resistance to Epidermal Growth Factor Receptor in Non-small Cell Lung Cancer
Erminia Massarelli

28 Predictive Tumor Biomarkers for EGFR Inhibitors
Lucia Kim, Geoffrey Liu, and Ming-Sound Tsao

29 Immunologic Approaches to Lung Cancer Therapy
Jay M. Lee, Steven M. Dubinett, and Sherven Sharma

30 Novel and Emerging Agents in NSCLC
Anne S. Tsao and Jack Roth

31 Novel Clinical Trial Designs for Metastatic Lung Cancer

Vassiliki A. Papadimitrakopoulou

32 Novel Statistical Models for NSCLC Clinical Trials
J. Jack Lee and Caleb T. Chu

33 Tumor Microenvironment, Angiogenesis Biology, and Targeted Therapy
John V. Heymach and Tina Cascone

34 Anti-angiogenic Agents in Metastatic NSCLC
Millie Das and Heather Wakelee

35 Targeting ALK Rearrangements
Justin F. Gainor and Alice T. Shaw

36 Non-Small Cell Lung Cancers (NSCLC) with Mutations in BRAF
Renata Ferrarotto and George R. Simon

37 Prognostic and Predictive Biomarker Signatures
Johannes R. Kratz and David M. Jablons

38 Brain Metastasis from Lung Cancer
Ritsuko Komaki and Amol J. Ghia

Index

The new fourth edition is now better than ever, incorporating the most recent work in the field of lung cancer research, diagnosis, and treatment. This book has always been well known and highly regarded for its concise presentation, but the editors decided to add 9 new chapters to this latest edition, while tightening the presentation in existing chapters and consolidating and re-formatting several other chapters so that an additional 7 chapters are nearly brand-new in content and approach: Almost half of this edition is new! The reader will now find here the very latest research in the identification of biomarkers to predict a high risk for developing lung cancer, which is vital information for implementing screening and prevention strategies. Also included is the newest lung cancer staging system, as well as a variety of surgical and radiation therapy techniques that make local tumor control more effective and less invasive. There is useful discussion of combined modality therapy and new chemotherapeutic agents, which are yielding higher response rates and improved survival when used in the adjuvant setting. Nearly a third of the book offers novel and emergent approaches to preventative, diagnostic, and therapeutic modalities in the treatment of lung cancer, with an emphasis on the best evidence available from the latest studies and clinical trials.